Results: The reviewed data shows that chronic application of stress responses may lead to alterations in the regulation of the HPA system, and the resulting hypercortisolism may be reflected in various psychoneuroendocrinological processes, such as the observed in the serotonergic system steroids, which was implicated in the origin and development of depression. Conclusions: The analysis of the interactions between the different components of this process, suggests that normalization of the HPA system, either directly through psychopharmacologic strategies, or indirectly through psychotherapeutic approaches oriented to improve the cognitive appraisal of stressful situations, may provide us with more effective diagnostic, preventive, and therapeutic methods in the treatment of widespread anxiety and mood disorders. D 2003 Elsevier Inc..
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